10 Botanicals and Nutraceuticals for Overstimulated Adrenals (Stage 1 HPA Axis Dysfunction)

The hypothalamic-pituitary-adrenal (HPA) axis is a complex system in the body that regulates our stress response. When we encounter a stressful situation, the HPA axis instructs the release of cortisol and catecholamines such as epinephrine and norepinephrine. However, chronic stress can lead to dysfunction of the HPA axis, resulting in a wide range of health problems. In this blog post, we’ll focus on the first stage of HPA axis dysfunction, the alarm phase, and discuss some botanicals and nutraceuticals that may help.

The alarm phase is the first stage of the HPA axis dysfunction, where the body’s initial response to stress is to release high levels of cortisol and catecholamines. This can lead to symptoms such as anxiety, irritability, and insomnia. The following is a list of some botanicals and nutraceuticals that may help with this stage. See our herbal dispensary stage 1 adrenal protocol for recommended products for each of these items.

1. Ashwagandha is an adaptogenic herb that has been traditionally used in Ayurvedic medicine to help the body cope with stress. It has wide ranging benefits including managing cortisol and blood sugar.
2. Holy basil (AKA tusli) is another adaptogenic herb that has been traditionally used in Ayurvedic medicine for its calming and stress-reducing properties. It has been shown to reduce cortisol levels and improve symptoms of anxiety. It additionally has an anti-inflammatory and antioxidant effect.
3. L-theanine is an amino acid found in green tea that has been shown to promote relaxation and reduce stress and anxiety. It works by increasing serotonin and dopamine levels in the brain. It has been shown to inhibit the sympathetic response, decreasing heart rate and salivary cortisol.
4. 5-HTP is a precursor to serotonin, a neurotransmitter that plays a role in mood regulation. Studies have shown that 5-HTP can reduce symptoms of anxiety and stress. It’s commonly used to help with sleep problems associated with elevated cortisol.
5. Passion flower is a calming herb, usually taken in tea form, that has been traditionally used to treat anxiety and insomnia. It has been shown to reduce cortisol levels.
6. Valerian root is another herb that has been traditionally used for its calming properties. It has been shown to improve sleep quality and reduce symptoms of anxiety.
7. Kava is a plant native to the South Pacific that has been traditionally used for its sedative and anxiolytic properties. It has been shown to reduce symptoms of anxiety and improve sleep quality.
8. Rehmannia is an herb used in traditional Chinese medicine to nourish the adrenal glands and support the HPA axis. It has been shown to reduce cortisol levels and improve symptoms of fatigue and stress.
9. Schisandra is an adaptogenic herb that has been traditionally used in Chinese medicine for its stress-reducing properties. It has been shown to reduce cortisol levels and improve cognitive function.
10. Polygala is an herb used in traditional Chinese medicine to support the HPA axis and improve cognitive function. It has been shown to reduce cortisol levels and improve symptoms of anxiety and depression.

Lifestyle Changes and HPA Axis Dysfunction

It’s also important to note that while supplements and herbs can be helpful for supporting the body during the alarm phase of HPA axis dysfunction, they should not be relied upon as the sole treatment. See our adrenal dysfunction post for more detailed information on lifestyle changes such as regular exercise, healthy eating, stress-reduction techniques, and adequate sleep are also important for supporting the body’s stress response.

Supplement Quality

When it comes to using supplements and herbs for HPA axis dysfunction, it’s important to choose high-quality products that are safe and effective. Not all supplements and herbs are created equal, and some may contain contaminants or be adulterated with other substances. Therefore, it’s important to do your research and choose a reputable brand that uses high-quality ingredients and follows good manufacturing practices. We only choose high quality products for our supplement protocols.

HPA axis dysfunction can be challenging. We often get “stuck” in a certain mode, but there are many botanicals and nutraceuticals that may help. The supplements listed here are just a few examples of natural remedies that can help support the body during this stressful time. As always, it’s important to speak with a healthcare professional before starting any new supplements or herbs.